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July 29, 2014  
HEART ATTACK CENTER: Get more information
  Prevention Center
  Survivor Center

Corporate Underwriter
Guidant
Guidant Corporation is a world leader in the design, development, manufacturing and marketing of innovative, high quality therapeutic medical devices for the treatment of cardiovascular and vascular diseases. Guidant's devices help patients with heart disease return to active and productive lives. Guidant provides physicians with leading-edge technologies for improved patient management and clinical outcomes.

MADIT II
Recently, Guidant's implantable defibrillators were approved for expanded indication by the FDA. This ruling was based on results from the landmark Multicenter Automatic Defibrillator Implantation Trial (MADIT) II. The trial indicated that use of Guidant's implantable defibrillators (ICDs) could potentially reduce mortality for heart attack survivors with impaired heart function -- namely, those whose ejection fractions are at or below 30 percent. In the ruling, the FDA stated that the defibrillators could protect the lives of at least 3 million heart attack survivors. Guidant is currently the only manufacturer of implantable defibrillators to have this approved labeling.

Implications of the Study
An important result of the MADIT II trial is the shift in philosophy for post-heart attack care. We now know that a heart attack can significantly lower one's ejection fraction, which, in turn, raises the risk of sudden cardiac death (SCD). According to the North American Society of Pacing and Electrophysiology (NASPE), sudden cardiac death (SCD) causes the death of more than 300,000 Americans each year. As a heart attack survivor, it is important that you and your doctor are aware of three numbers: your cholesterol, your blood pressure, and your ejection fraction. By educating yourself on these three aspects of your cardiac health, you will take one step closer toward preventing SCD.

"People now should know this like what their blood pressure is, what their cholesterol level is and what their ejection fraction is. Low ejection fraction identifies a high risk for Sudden Cardiac Death, and at the present time the only treatment, the only preventive treatment for Sudden Cardiac Death is in fact the implantable defibrillator. There are no effective drugs to prevent Sudden Cardiac Death, which makes up about half of the death in individuals who have low ejection fractions."
- Dr. Arthur Moss, principal investigator of the MADIT II trial

In the News

  • FDA Approves Expanded Indication for Guidant Implantable Defibrillators
  • Heart Device Combines Two Types of Implants
  • Implantable Defibrillators May Help Heart Patients

    Follow the link below to learn more about Guidant's medical technology. Worldwide, Guidant products help improve the quality of care and reduce costs for nearly three-quarters of a million patients who receive interventional heart-related procedures each year.

  • Click here to learn more

    Remember, you should always consult with your physician about which care solution will be best for your situation.

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    Patient Education from


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    Click here to learn more about Ejection Fraction

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