Heart1.com: Great Information, Real Community, Better Living.
 Register
 Login
 Main Page
 Heart News
Feature Story
 Education Center
Conditions
Procedures
Diagnostics
 Heart Attack Center
Prevention
Survivors
Dr. Tod Engelhardt  Heart
 Hero™

Dr. Tod Engelhardt:
Combating Major Blood Clots.
About Heroes
 Join the Discussion  in  Our Forums
 Community
Heart1 Forums
Patient Stories
 Reference
Online Resources
Video Library
advertisement
Search the Body1 Network
September 24, 2017  
HEART NEWS: Feature Story

  • Print this Article
  • Email this Article
  • Links/Reprints
  • leaf veins

    New Ability To Regrow Blood Vessels Holds Promise For Treatment Of Heart Disease


    April 03, 2012
    University of Texas at Austin researchers have demonstrated a new and more effective method for regrowing blood vessels in the heart and limbs - a research advancement that could have major implications for how we treat heart disease, the leading cause of death in the Western world. 

    The treatment method developed by Cockrell School of Engineering Assistant Professor Aaron Baker could allow doctors to bypass surgery and instead repair damaged blood vessels simply by injecting a lipid-incased substance into a patient. Once inside the body, the substance stimulates cell growth and spurs the growth of new blood vessels from pre-existing ones. 

    The method has been tested successfully on rats, and findings of the study were published recently in the Proceedings of the National Academy of Sciences. 

    "Others have tried using growth factors to stimulate vessel growth in clinical trials and have not been successful," said Baker, a faculty member in the school's Department of Biomedical Engineering. "We think that a major reason for this is that previous methods assumed the diseased tissues retained the ability to respond to a growth stimulus. Our method basically delivers extra components that can restore growth factor responsiveness to the tissue of patients with long-standing clinical disease." 

    The ability to regrow blood vessels could prove crucial to treating chronic myocardial ischemia disease, which affects up to 27 million patients in the U.S. and leads to a reduction of blood flow in the heart and lower limbs - ultimately, causing organ dysfunction and failure. 

    Central ischemia, which effects the heart, occurs when the coronary vessels that feed blood to the heart become blocked or narrow due to a buildup of fatty deposits, or plaques. Such plaques are typically the result of a prolonged unhealthy diet or smoking, and factors like age, high blood pressure and diabetes increase the risks of the disease, Baker said. 

    Doctors have typically treated ischemia by physically opening the closed artery with a stent or surgically rerouting blood flow to the poorly perfused tissue. Both methods have limitations, however, and are not effective long-term. 

    The new method introduced by Baker and his research team builds off of a promising revascularization approach that, up until now, has shown limited efficacy in clinical trials for treating human disease. 

    The method combines a growth factor - a substance capable of stimulating cellular growth, proliferation and cellular differentiation, as well as healing wounds - known as fibroblast growth factor 2 (FGF-2) with a lipid-embedded receptor to enhance its activity. 

    A challenge for scientists and engineers, however, has been getting FGF-2 to bind with cell receptors - the very molecules often found on the surface of the cell that receive chemical signals and direct activity in the cell from outside sources. 

    To overcome this, Baker's method embeds the growth factors in synthetic lipid-based nanoparticles containing a coreceptor known as syndecan-4. The nanoparticles containing co-receptors that, when delivered with the growth factor, enable improved cell binding so that the growth factor can direct the targeted cell to divide, proliferate and form new cells for tissue regrowth. 

    The incased substance was injected into rats with hindlimb ischemia and stimulated a complete recovery from the ischemia in just seven days. 

    "We hope this research will increase our understanding of how tissues become resistant to revascularization therapies and may lead to more effective treatments for this widespread and debilitating disease," said Baker, who was recognized last year with the National Institutes of Health Director's New Innovator Award. 

    Designed to support unusually creative new investigators with highly innovative research ideas at an early stage of their career, the award provides Baker with $1.5 million over five years to study and develop ways to regrow small blood vessels. With it, Baker is studying why previous attempts to restore blood flow to the heart have not been effective. His research aims to design new molecular tools and drug delivery methods to enable blood vessel growth in patients with diseases such as diabetes. 

    Discuss in the Heart1 forums!

    Photo: Stewart Butterfield

    Last updated: 03-Apr-12

    Comments

  • Add Comment
  •    
    Interact on Heart1

    Discuss this topic with others.
     
    Feature Archives

    Heart Disease Patients Need to Exercise to Benefit from the Protective Effects of Wine

    Effective Treatment for Heart Failure Possible Following Discovery of Heart Molecule

    Significant Decrease in Heart Disease after Prison Smoking Bans

    Heart Failure Patients Who Sleep Poorly Are at Double the Risk for Hospitalization

    Long-Term Survival Possible for Pediatric Heart Transplant Patients

    Next 5 Features ...

    More Features ...
       
     
    Related Multimedia

    Interview with James Spies, M.D. - The Effects of Less Functioning Vaults

    Interview with James Spies, M.D. about Treatments for Fibroids

    The Benefits of Implantable Defibrillators - Interview with Dr. Coman

    More Features ...
     
    Related Content
    Heart Failure Patients Who Sleep Poorly Are at Double the Risk for Hospitalization

    Study: New Bypass Technique Holds Promise

    Report: Heart Disease Is a Global Problem

    Study Says Statin Drugs Can Help Kids

    Discoveries Show How Obesity Kills

    More Features ...
     
    Home About Us Press Jobs Advertise With Us Contact Us
    advertisement
    © 2017 Body1 All rights reserved.
    Disclaimer: The information provided within this website is for educational purposes only and is not a substitute for consultation with your physician or healthcare provider. The opinions expressed herein are not necessarily those of the Owners and Sponsors of this site. By using this site you agree to indemnify, and hold the Owners and Sponsors harmless, from any disputes arising from content posted here-in.