Heart1.com: Great Information, Real Community, Better Living.
 Main Page
 Heart News
Feature Story
 Education Center
 Heart Attack Center
Dr. Tod Engelhardt  Heart

Dr. Tod Engelhardt:
Combating Major Blood Clots.
About Heroes
 Join the Discussion  in  Our Forums
Heart1 Forums
Patient Stories
Online Resources
Video Library
Search the Body1 Network
May 22, 2019  
HEART NEWS: Feature Story

  • Print this Article
  • Email this Article
  • Links/Reprints
  • Avastin Increases Risk of Heart Ailments

    Avastin Increases Risk of Heart Ailments

    August 13, 2004

    The Food and Drug Administration and Genentech have warned doctors that Avastin, used to treat colorectal cancer, increases patients' risk of suffering heart ailments - including chest pain, strokes, mini-strokes and heart attacks.

    Avastin also raised the risk of patients dying from those heart ailments.

    Colleen Sweeney, Genentech spokeswoman, said Friday that some patients taking Avastin died from those heart ailments but could not say how many. "I don't have the data," Sweeney said.

    During clinical trials before the drug's approval, one patient died but a "clear relationship" could not be determined between Avastin use and the heart-related fatality, she said. Additional analyses led to the issuance of the drug warning.

    "Right now, we're working with the FDA, with these analyses, to update the Avastin label," she said.

    Genentech would not say how many patients were prescribed Avastin after FDA approval. "We don't give out prescription information," Sweeney said.

    But the company did tell health care providers in its warning letter that patients whose cancer has spread to the rest of their bodies were twice as likely to suffer serious heart ailments if they received Avastin with their chemotherapy. The highest-risk individuals had a past history of such heart problems and were older than 65.

    The FDA on Feb. 26 approved the product - a genetically engineered version of a mouse antibody containing mouse and human components - after testing showed patients receiving the drug intravenously lived an additional five months. The drug, the first approved angiogenesis inhibitor to treat colorectal cancer, works by blocking new blood vessels, essentially depriving cancer cells of the oxygen and nutrients they need to thrive.

    According to the Centers for Disease Control, cancer of the colon or rectum is the nation's third most common cancer and is the second leading cause of cancer-related deaths.


    On the Net:

    Avastin: http://www.gene.com/gene/products/information/oncology/avastin/index.jsp

    Last updated: 13-Aug-04


  • Add Comment
    Interact on Heart1

    Discuss this topic with others.
    Feature Archives

    Heart Disease Patients Need to Exercise to Benefit from the Protective Effects of Wine

    Effective Treatment for Heart Failure Possible Following Discovery of Heart Molecule

    Significant Decrease in Heart Disease after Prison Smoking Bans

    Heart Failure Patients Who Sleep Poorly Are at Double the Risk for Hospitalization

    Long-Term Survival Possible for Pediatric Heart Transplant Patients

    Next 5 Features ...

    More Features ...
    Related Multimedia

    Plaques/fatty deposits as a cause for a heart attack

    The risk of cardiac death due to a lower ejection fraction

    The function of a defibrillator

    More Features ...
    Related Content
    Studies: New Blood Thinners No Better

    Grandma’s Unplugged! Mystery Pains Turn into Triple Bypass

    Heart Attacks Linked to Long Hours at Work

    Atrioventricular Block/Heart Block

    Heart Attack Warning Signs

    More Features ...
    Home About Us Press Jobs Advertise With Us Contact Us
    © 2019 Body1 All rights reserved.
    Disclaimer: The information provided within this website is for educational purposes only and is not a substitute for consultation with your physician or healthcare provider. The opinions expressed herein are not necessarily those of the Owners and Sponsors of this site. By using this site you agree to indemnify, and hold the Owners and Sponsors harmless, from any disputes arising from content posted here-in.